Trimethylchlorosilane 99%

CAS No.: 75-77-4

Molecular Formula C₃H₉SiCl                                         Molar Weight: 108.64 g/mol

Property:

Trimethylsilyl chloride, also known as TMCS is a silyl halide, with a variety of different uses in chemistry. TMCS has the formula (CH3)3SiCl, and under standard conditions TMCS is a colourless liquid, which is stable in the absence of water. It can be prepared from silicon tetrachloride by nucleophillic substitution of three of the chloride groups with a nucleophillic methyl source such as methyllithium, however the compound is readily available commercially.

Use:

TMCS has variety of uses in chemistry, both as a source of the trimethylsilyl group, and as an anhydrous source of chlorides. Functional groups such as alcohols and amines readily undergo reaction with Trimethylsilyl chloride, giving trimethylsilyl ethers and trimethylsilyl amines. These new groups can be used as protecting groups for the original functional group, however the lability of the trimethylsilyl group restricts their utility. The TMCS can also be used to increase a compounds volatility, enabling gas chromatography of normally non-volatile substances such as glucose. Trimethylsilyl chloride also reacts with metal acetylides to give trimethylsilyl alkynes, which are useful protected forms of alkynes.

Package:

TMCS is packed in 160kg metal drums

Keywords:

Trimethylsilyl chloride, Chlorotrimethylsilane, trimethylsilylation, TMSCI, TMCS