CAS NO.: 1264-72-8
EINECS: 215-034-3
Molecular Formula: 2(C52H98N16O13).5(H2SO4)
Molecular Weight: 2801.27
Molecular Structure:
Property：
Melting point 200-220 ºC. There are two
forms of colistin available commercially: colistin sulfate
and colistimethate sodium (colistin methanesulfonate sodium,
colistin sulfomethate sodium). Colistin sulfate is cationic; colistimethate sodium is anionic.
Colistin sulfate is
stable, but colistimethate sodium is readily hydrolysed to a
variety of methanesulfonated derivatives. Colistin sulfate
and colistimethate sodium are eliminated from the body by
different routes. With respect to Pseudomonas aeruginosa,
colistimethate is the inactive prodrug of colistin. The two
drugs are not interchangeable.
Specifications：
|
Item |
Index |
| Potency |
Dried Basis
19000IU/mg min. |
| PH Value |
4.0-6.0 |
|
Residue On Ignition |
1.0%max |
| Loss On Drying |
3.5%max |
|
Optical Rotation |
-63。--73。 |
|
Assay |
77%min. |
| Sulfate |
16.0-18.0% |
| E3 |
10.0%max. |
| E1-I |
10.0%max. |
| E1-7MOA |
10.0%max. |
| Related
Substances |
4.0%max. |
| Total Related
Substances |
23.0%max. |
Usage:
Colistin sulphate is used to treat
certain stomach, bowel and digestive tract infections.
Cyclic polypeptide antibiotic produced by Bacillus
polymyxa. Complex mixture of at least 30 components,
primarily colistins A and B. [a]D= -65?(c= 1, Water)
LOD: 3%. Colistin sulfate may be used to treat
intestinal infections, or to suppress colonic flora. Colistin sulfate is also used as topical creams,
powders, and otic solutions
Package and Storage:
25kg fiber drum and kept in cool and air
place for 2 years.
Keyword：
Colistin sulphate;
N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide
sulfate
