CAS NO.: 53003-10-4 EINECS: 258-290-1
Molecular Formula: C42H70O11 Molecular Weight: 751.01
Molecular Structure:
Property:
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
Specifications：
|
Item |
Index |
| Appearance |
Pale Brown Powder of Uniform Color |
| Identification |
Meet the criterion |
| Loss On Drying |
5.0% max. |
| Granularity |
250 micron sieve:1% max. retsined
150 micron sieve: 50% min. through
|
| PH |
7.5-10.5 |
| Heavy Metals |
0.002% max. |
| Arsenic Salt |
0.0002% max. |
| Content |
25%-29% |
Usage:
Salinomycin is used in chicken fodder as a coccidiostat.
Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer drug (paclitaxel) in mice. The study screened 16 000 different chemical compounds and found that only a small subset, including
salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse. The mechanism of action by which
Salinomycin kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen.
Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.
Package and Storage:
Keep in shaded, cool 25kg fiber drum and air places. The shelf time is 2 years.
Key Words:
Monensin
Salinomycin
(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid
